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1

Development of Thiophenic Analogues of Benzothiadiazine Dioxides as New Powerful Potentiators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid (AMPA) Receptors

Francotte, Pierre, Goffin, Eric, Fraikin, Pierre, Graindorge, E., Lestage, Pierre, Danober, Laurence, Challal, Sylvie, Rogez, Nathalie, Nosjean, Olivier, Caignard, Daniel-Henri, Pirotte, Bernard, de T

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2013

2

Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators

Pierre Francotte, Pascal de Tullio, Tchao Podona, Ousmane Diouf, Pierre Fraikin, Pierre Lestage, Laurence Danober, Jean-Yves Thomas, Daniel-Henri Caignard, Bernard Pirotte

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 382 KB

english, 2008

3

Mechanisms and functional significance of a slow inhibitory potential in neurons of the lateral amygdala

Laurence Danober, Hans-Christian Pape

Journal:

European Journal of Neuroscience

Année:

1998

Langue:

english

Fichier:

PDF, 838 KB

english, 1998

4

GABAA receptor impairment in the genetic absence epilepsy rats from Strasbourg (GAERS): an immunocytochemical and receptor binding autoradiographic study

R Spreafico, T Mennini, L Danober, A Cagnotto, M.C Regondi, A Miari, A De Blas, M Vergnes, G Avanzini

Journal:

Epilepsy Research

Année:

1993

Langue:

english

Fichier:

PDF, 2.79 MB

english, 1993

5

Thalamic NMDA transmission in a genetic model of absence epilepsy in rats

C. Koerner, L. Danober, A. Boehrer, C. Marescaux, M. Vergnes

Journal:

Epilepsy Research

Année:

1996

Langue:

english

Fichier:

PDF, 664 KB

english, 1996

6

New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors

Dintilhac, Gaëlle, Arslan, Deniz, Dilly, Sébastien, Danober, Laurence, Botez, Iuliana, Lestage, Pierre, Pirotte, Bernard, de Tullio, Pascal

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 327 KB

english, 2011

7

Effects of cholinergic drugs on genetic absence seizures in rats

Laurence Danober, Antoine Depaulis, Christian Marescaux, Marguerite Vergnes

Journal:

European Journal of Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 505 KB

english, 1993

8

Modulatory effects of S 38232, a non α-7 containing nicotine acetylcholine receptor agonist on network activity in the mouse hippocampus

Laura Lagostena, Laurence Danober, Sylvie Challal, Pierre Lestage, Elisabeth Mocaër, Caryn Trocmé-Thibierge, Enrico Cherubini

Journal:

Neuropharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 1018 KB

english, 2010

9

P1-406 S 18986, positive allosteric modulator of AMPA receptors as a novel cognition enhancer in rodents

Pierre J. Lestage, Laurence Danober, Brian P. Lockhart, Anita Roger, Cécile Lebrun, Patrice Desos, Alex Cordi

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 167 KB

english, 2004

10

P1-415 S18986, enhances BDNF expression in rat primary neuronal cultures

Brian P. Lockhart, Marianne Rodriguez, Sandra Catesson, Sophie Mourlevat, Philippe Peron, Nadège Villain, Laurence Danober, Jean A. Boutin, Jean-Pierre Galizzi, Pierre J. Lestage

Journal:

Neurobiology of Aging

Année:

2004

Langue:

english

Fichier:

PDF, 319 KB

english, 2004

11

Pathophysiological mechanisms of genetic absence epilepsy in the rat

L Danober, C Deransart, A Depaulis, M Vergnes, C Marescaux

Journal:

Progress in Neurobiology

Année:

1998

Langue:

english

Fichier:

PDF, 918 KB

english, 1998

12

Electrophysiological studies on the hippocampus and prefrontal cortex assessing the effects of amyloidosis in amyloid precursor protein 23 transgenic mice

S Roder, L Danober, M.F Pozza, K Lingenhoehl, K.-H Wiederhold, H.-R Olpe

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 528 KB

english, 2003

13

The amygdala is critical for seizure propagation from brainstem to forebrain

E Hirsch, L Danober, S Simler, A Pereira de Vasconcelos, B Maton, A Nehlig, C Marescaux, M Vergnes

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 357 KB

english, 1997

14

Strychnine-sensitive glycine responses in neurons of the lateral amygdala: an electrophysiological and immunocytochemical characterization

L Danober, H.-C Pape

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 390 KB

english, 1998

15

DRUG FOCUS: S 18986: A Positive Allosteric Modulator of AMPA-Type Glutamate Receptors Pharmacological Profile of a Novel Cognitive Enhancer

Katy Bernard, Laurence Danober, Jean-Yves Thomas, Cécile Lebrun, Carmen Muñoz, Alex Cordi, Patrice Desos, Pierre Lestage, Philippe Morain

Journal:

CNS Neuroscience & Therapeutics

Année:

2010

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2010

16

New Fluorinated 1,2,4-Benzothiadiazine 1,1-Dioxides: Discovery of an Orally Active Cognitive Enhancer Acting through Potentiation of the 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors

Francotte, Pierre, Goffin, Eric, Fraikin, Pierre, Lestage, Pierre, Van Heugen, Jean-Claude, Gillotin, Florian, Danober, Laurence, Thomas, Jean-Yves, Chiap, Patrice, Caignard, Daniel-Henri, Pirotte, Be

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2010

17

Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxide Scaffold

Nørholm, Ann-Beth, Francotte, Pierre, Olsen, Lars, Krintel, Christian, Frydenvang, Karla, Goffin, Eric, Challal, Sylvie, Danober, Laurence, Botez-Pop, Iuliana, Lestage, Pierre, Pirotte, Bernard, Kastr

Journal:

Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 3.35 MB

english, 2013

18

C-fos expression after single and kindled audiogenic seizures in Wistar rats

Simler, Simone, Hirsch, Edouard, Danober, Laurence, Motte, Jacques, Vergnes, Marguerite, Marescaux, Christian

Journal:

Neuroscience Letters

Année:

1994

Langue:

english

Fichier:

PDF, 727 KB

english, 1994

19

Nucleus basalis lesions suppress spike and wave discharges in rats with spontaneous absence-epilepsy

Danober, L., Vergnes, M., Depaulis, A., Marescaux, C.

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 3.31 MB

english, 1994

20

Mesopontine cholinergic control over generalized non-convulsive seizures in a genetic model of absence epilepsy in the rat

Danober, L., Depaulis, A., Vergnes, M., Marescaux, C.

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 1.13 MB

english, 1995

21

Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors †

Francotte, Pierre, de Tullio, Pascal, Goffin, Eric, Dintilhac, Gaëlle, Graindorge, Emmanuel, Fraikin, Pierre, Lestage, Pierre, Danober, Laurence, Thomas, Jean-Yves, Caignard, Daniel-Henri, Pirotte, Be

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 94 KB

english, 2007

22

Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces

Nørholm, Ann-Beth, Francotte, Pierre, Goffin, Eric, Botez, Iuliana, Danober, Laurence, Lestage, Pierre, Pirotte, Bernard, Kastrup, Jette S., Olsen, Lars, Oostenbrink, Chris

Journal:

Journal of Chemical Information and Modeling

Année:

2014

Langue:

english

Fichier:

PDF, 2.63 MB

english, 2014

23

Ring-Fused Thiadiazines as Core Structures for the Development of Potent AMPA Receptor Potentiators

Pirotte, B., Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lesur, B., Botez, I., Caignard, D.-H., Lestage, P., de Tullio, P.

Journal:

Current Medicinal Chemistry

Année:

2010

Fichier:

PDF, 177 KB

2010

24

Ring-Fused Thiadiazines as Core Structures for the Development of Potent AMPA Receptor Potentiators

Pirotte, B., Francotte, P., Goffin, E., Fraikin, P., Danober, L., Lesur, B., Botez, I., Caignard, D.-H., Lestage, P., de Tullio, P.

Journal:

Current Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 177 KB

english, 2010

25

S 44858, a positive allosteric modulator of ampa receptors and GluN2B selective nmda receptors antagonist, prevents the disruption of synaptic plasticity induced by Aβ oligomers

Danober, Laurence, Rönicke, Raik, Reymann, Klaus, Ondrejcak, Tomas, Zhang, Dainan, Hu, Neng-Wei, Rowan, Michael J., Desos, Patrice, Cordi, Alex, Lestage, Pierre

Journal:

Alzheimer's & Dementia

Année:

2015

Langue:

english

Fichier:

PDF, 49 KB

english, 2015

26

In vivo characterization of s44858, a positive allosteric modulator of ampa receptors and GluN2B selective non-competitive nmda antagonist

Lestage, Pierre, Danober, Laurence, Thomas, Jean-Yves, Krentner, Martine, Roger, Anita, Albinet, Karine, Louis, Caroline, Bertaina-Anglade, Valérie, Kazem, Ali, Béracochéa, Daniel, Bordet, Regis, Papp

Journal:

Alzheimer's & Dementia

Année:

2015

Langue:

english

Fichier:

PDF, 51 KB

english, 2015

27

In vitro characterization of s44858: A positive allosteric modulator of ampa receptors and GluN2B selective non-competitive nmda receptors antagonist

Danober, Laurence, Thomas, Jean-Yves, Challal, Sylvie, Rogez, Nathalie, Albinet, Karine, Villain, Nadège, Mony, Laétitia, Paoletti, Pierre, Bertrand, Daniel, Wagner, Stéphanie, Desos, Patrice, Cordi,

Journal:

Alzheimer's & Dementia

Année:

2015

Langue:

english

Fichier:

PDF, 72 KB

english, 2015

28

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure–Activity Relationship at AMPA Receptors

Larsen, Anja Probst, Francotte, Pierre, Frydenvang, Karla, Tapken, Daniel, Goffin, Eric, Fraikin, Pierre, Caignard, Daniel-Henri, Lestage, Pierre, Danober, Laurence, Pirotte, Bernard, Kastrup, Jette S

Journal:

ACS Chemical Neuroscience

Année:

2016

Langue:

english

Fichier:

PDF, 2.19 MB

english, 2016

29

Prélèvements d’organes à partir de donneurs très âgés : mythe ou réalité ?

Durin, Laurent, Danober, Jean Christophe, Mougenot, Gérard, Bastien, Olivier, Frimat, Luc, Losser, Marie Reine, Audibert, Gérard

Journal:

Anesthésie & Réanimation

Année:

2015

Langue:

french

Fichier:

PDF, 151 KB

french, 2015

30

CHANGES IN FRONTOCORTICAL INTERSTITIAL FLUID LEVELS OF BETA-AMYLOID AND TAU PROTEIN IN TRANSGENIC MICE MODELS OF ALZHEIMER'S DISEASE

Gobert, Alain, Rollin-Jego, Gaelle, Iop, Fabrice, Rivet, Jean Michel, Favale, Dominique, Danober, Laurence, Dix, Sophie, Czech, Christian, Laurence, Ozmen, Richardson, Jill, Schenker, Esther

Journal:

Alzheimer's & Dementia

Année:

2014

Langue:

english

Fichier:

PDF, 55 KB

english, 2014

31

Synaptic mechanisms of NMDA-mediated hyperpolarization in lateral amygdaloid projection neurons

Danober, Laurence, Heinbockel, Thomas, Driesang, Robert B., Pape, Hans-Christian

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 1.00 MB

english, 2000

32

Pharmacological profile of S 76892, a new ligand at nicotinic α7-subtype receptors

Danober, L., Louis, C., Rogez, N., Thomas, J.Y., Dores, G. Das, Gandon, M.H., Hugot, A., Beracochea, D., Krazem, A., Bertaina-AngladE, V., Rimet, D., Pillot, T., Bertrand, M., Fourquez, J.M., Botez, I

Journal:

Biochemical Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 310 KB

english, 2015

33

In vivo pharmacological profile of S 38093, a novel histamine H3 receptor inverse agonist

Panayi, Fany, Sors, Aurore, Bert, Lionel, Martin, Brigitte, Rollin-Jego, Gaelle, Billiras, Rodolphe, Carrié, Isabelle, Albinet, Karine, Danober, Laurence, Rogez, Nathalie, Thomas, Jean-Yves, Pira, Lui

Journal:

European Journal of Pharmacology

Année:

2017

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2017

34

Quantitative assessment of oligomeric amyloid beta peptide binding to alpha7 nicotinic receptor

Cecon, Erika, Dam, Julie, Luka, Marine, Gautier, Clément, Chollet, A.M., Delagrange, Philippe, Danober, Laurence, Jockers, Ralf

Journal:

British Journal of Pharmacology

Année:

2019

Fichier:

PDF, 1.29 MB

2019

35

P3-043: COGNITIVE PROFILE OF S 68890, AN ALLOSTERIC MODULATOR OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS

Danober, Laurence, Dores, Guillaume Das, Louis, Caroline, Llopis, Karine, Dumas, Nathalie, Liard, Catherine, Girardon, Sylvie, Catherine, Le Quement, Bureau, Marie, Krazem, Ali, BÃ©racochÃ©a, Daniel,

Journal:

Alzheimer's & Dementia

Année:

2019

Fichier:

PDF, 393 KB

2019

36

P2-065: IN VITRO PHARMACOLOGICAL CHARACTERIZATION OF S68890, AN ALLOSTERIC MODULATOR OF ALPHA7 NICOTINIC RECEPTORS

Danober, Laurence, Kambara, Kumiko, Bertrand, Sonia, Bertrand, Daniel, Benoist, Alain, Fourquez, Jean-Marie, Chollet, Anne-Marie, Gloanec, Philippe, Jeggo, Ross

Journal:

Alzheimer's & Dementia

Année:

2019

Fichier:

PDF, 182 KB

2019